Inhalation Toxicity

A major focus area for the Science Consortium is developing and gaining scientific confidence in effective and efficient approaches to assess the potential effects of inhaled chemicals on humans. We kicked off this work in 2015 and 2016, by hosting webinars and two workshops focused on alternative approaches for inhalation toxicity testing. The workshops, which were co-organized with the US NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM), launched various initiatives, including:

  • Funding the development and characterization of EpiAlveolar, a human tissue model of the lower respiratory tract (see here)
  • Conducting proof-of-concept testing to show how in vitro approaches can be used to assess the toxicity of inhaled chemicals (INSPiRE Initiative, see here)
  • Funding research to show that human precision-cut lung slices can be used following cryopreservation (see here)
  • Hosting webinars on non-animal approaches for inhalation toxicity testing, which can be viewed here
  • Donating in vitro inhalation exposure devices to laboratories (see here)
  • Awarding researchers with free human tissue models to assess the effects of inhaled substances (see here)