Acute Systemic Toxicity

With the goal of developing a strategy to replace the in vivo acute systemic toxicity test methods, the PETA Science Consortium International co-sponsored a series of webinars and a workshop on 24-25 September 2015 in Bethesda, MD. For more details about the workshop and to view the workshop presentation slides, please see here.

The workshop proceedings were published in Toxicology In Vitro in 2017, and additional information was published in Regulatory Toxicology and Pharmacology in 2018.  The Science Consortium also delivered the keynote presentation at a 2019 follow-up workshop on acute systemic toxicity testing (workshop report in preparation).

In follow-up to the September 2015 workshop, the Science Consortium also co-organized a series of six webinars and a workshop focused on alternative approaches for acute inhalation toxicity testing (here) and donated five VITROCELL® inhalation exposure devices for researchers to assess the effects of inhaled substances in vitro (here).

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Acute systemic toxicity testing is conducted to predict the effects of acute exposure to a substance. In the animal test, acute exposure is defined as exposure to a substance for less than 24 hours and the main routes of exposure are oral, dermal, and inhalation. Acute systemic toxicity testing may be required by various regulatory agencies, including the U.S. Environmental Protection Agency’s Office of Pesticide Programs.

Reading on acute systemic toxicity: