With the goal of developing a strategy to replace the in vivo acute systemic toxicity test methods, PETA Science Consortium International co-sponsored a series of webinars and a workshop on 24-25 September 2015 in Bethesda, MD. For more details about the workshop and to view the workshop presentation slides, please see here.
The workshop proceedings were published in Toxicology In Vitro in 2017, and additional information was published in Regulatory Toxicology and Pharmacology in 2018. The Science Consortium also delivered the keynote presentation at a 2019 follow-up workshop on acute systemic toxicity testing (workshop report in preparation).
In follow-up to the September 2015 workshop, the Science Consortium also co-organized a series of six webinars and a workshop focused on alternative approaches for acute inhalation toxicity testing (here) and donated five VITROCELL® inhalation exposure devices for researchers to assess the effects of inhaled substances in vitro (here).
Acute systemic toxicity testing is conducted to predict the effects of acute exposure to a substance. In the animal test, acute exposure is defined as exposure to a substance for less than 24 hours and the main routes of exposure are oral, dermal, and inhalation. Acute systemic toxicity testing may be required by various regulatory agencies, including the U.S. Environmental Protection Agency’s Office of Pesticide Programs.
Reading on acute systemic toxicity:
- Predictive Models for Acute Oral Systemic Toxicity: A Workshop to Bridge the Gap from Research to Regulation (2018)
- Status of Acute Systemic Toxicity Testing Requirements and Data Uses by U.S. Regulatory Agencies (2018)
- Workshop report: Alternative Approaches for Identifying Acute Systemic Toxicity: Moving from Research to Regulatory Testing (2017)
- OECD Guidance Document on Considerations for Waiving or Bridging of Mammalian Acute Toxicity Tests. Series on Testing & Assessment No. 237. (2016)
- National Academies Report on the Application of Modern Toxicology Approaches for Predicting Acute Toxicity for Chemical Defense (2015)
- EURL ECVAM Strategy to Replace, Reduce and Refine the Use of Animals in the Assessment of Acute Mammalian Systemic Toxicity (2014)
- EPA OPP Strategic Vision for Adopting 21st Century Science Methodologies