PETA Science Consortium International and Epithelix are pleased to announce the winner of the 2023 award for three-dimensional reconstructed human respiratory tissues from Epithelix. Epithelix’s human cell–based tissue models mimic different regions of the respiratory tract and can be used for testing cosmetics, pharmaceuticals, medical device extracts, industrial chemicals, pesticides, and household products.
Dr Suzanne Cloonan of Trinity College Dublin received a $15,000 (~€15,237) award redeemable for Epithelix tissues (MucilAir™, SmallAir™, or AlveolAir™) and/or primary human alveolar macrophages. She will use the tissues to test the effects of cigarette smoke and bacterial infection in the context of lung diseases.
“There is an urgent need to develop in vitro models that physiologically, metabolically and immunologically mimic the alveolar space. This award will allow us to try and develop such a model to test new therapeutic interventions for infectious exacerbations in Chronic Obstructive Pulmonary disease.”— Dr Suzanne Cloonan
In 2018, PETA Science Consortium International and Epithelix awarded researchers from the United States, the United Kingdom, and Germany free three-dimensional (3-D) reconstructed human respiratory tissue models manufactured by Epithelix. After receiving proposals from all around the world, three researchers were chosen based on their proposals’ scientific merit and potential to use the tissues to replace animals in inhalation testing.
First Place ($5,000 award)
Kristine Nishida, from the Division of Pulmonary and Critical Care Medicine at Johns Hopkins School of Medicine, will expose the 3-D tissues to cigarette smoke to elucidate the mechanism underlying the progression of chronic obstructive pulmonary disease (COPD). She will also study tissues from human donors with COPD to gain a deeper understanding of the disease pathogenesis and how to reverse the effects.
“I am so honored to receive this wonderful award! The MucilAir cells will allow us to elucidate the mechanisms that occur in human cells isolated from several different COPD and non-diseased donors in a fully differentiated air-liquid interface culture. We will be able to expose the tissues at air-liquid interface to whole cigarette smoke and fully detail the changes that occur in the epithelium that we couldn’t otherwise do in an animal model.”— Kristine Nishida
Second Place ($2,500 award each)
Dr Chang Guo, Public Health England, will use the tissues for toxicity testing of carbon nanotubes.
Dr Richard Gminski, University of Freiburg, will use the tissues to evaluate the efficacy of drugs on Klebsiella pneumoniae, an antibiotic-resistant bacterium that poses a health threat to hospital patients worldwide.