The Science Consortium at WC11

11th World Congress on Alternatives and Animal Use in the Life Sciences
Virtual Congress
23 August–2 September 2021

CHAIRED SESSIONS

Session Title: Replacing Fetal Bovine Serum (FBS) – Innovative Alternatives and Transition Strategies
Session ID: 167
Day/Time: Monday, 23 August, 9:30–11:30 am EDT (3:30–5:30 pm CEDT)
Chair: Tilo Weber, German Animal Welfare Federation/Animal Welfare Academy
Co-Chair: Katherine Groff, PETA Science Consortium International e.V.
Presentations:

  • Tilo Weber, German Animal Welfare Federation/Animal Welfare Academy: “Dam Transportation, Fetal Suffering and Legal Objections – Why Fetal Bovine Serum Should Be a Thing of the Past”
  • Jan van der Valk, 3Rs-Centre Utrecht Life Sciences, Utrecht University: “Replacing Foetal Bovine Serum: A Piece of Cake?”
  • Karen Bieback, Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University; and the German Red Cross Blood Donor Service: “Replacing Fetal Bovine Serum (FBS) – Innovative Alternatives and Transition Strategies”
  • Aline Chary, Luxembourg Institute of Science and Technology: “Towards the Replacement of Foetal Bovine Serum in Cell Culture Application: the Example of A549 Cells”
  • Carol Treasure, XCellR8 Ltd: “What is Truly Animal-Free Testing? Moving Towards Animal-Product-Free In Vitro Systems”


Session Title: Modern, Mechanistic Approaches to Cancer Risk Assessment
Session ID: 111
Day/Time: Monday, 23 August, 1–3 pm EDT (7–9 pm CEDT)
Chair: Gina Hilton, PETA Science Consortium International e.V.
Presentations:

  • Warren Casey, US National Toxicology Program: “Modernizing the NTP’s Carcinogenicity Testing Program”
  • Chris Corton, US Environmental Protection Agency: “Towards Replacing the Two-Year Bioassay With Short-Term NAMs: Genomic and Nongenomic Activation Levels Can Identify Rat Liver Tumorigens”
  • Kate Guyton, International Agency for Research on Cancer: “Application of the Key Characteristics in Carcinogen Hazard Identification”
  • Gina Hilton, PETA Science Consortium International e.V.: “ReCAAP – Carcinogenicity Waivers for Food-Use Pesticide Registration”
  • Nathalie Delrue, Organisation for Economic Co-operation and Development: “Developing an Integrated Testing Approach to Testing and Assessment for Non-Genotoxic Carcinogens”
  • Federica Madia, Joint Research Centre, European Commission: “Advancing Carcinogenicity Assessment: A Novel Methodological Approach to Integrate Information and Further the Impact on the 3Rs”


Session Title: A Global Movement to Improve Science Using Animal-Free Antibodies
Session ID: 118
Day/Time: Thursday, 26 August, 9–11 am EDT (3–5 pm CEDT)
Chair: Alison Gray, AFABILITY
Co-Chair: Katherine Groff, PETA Science Consortium International e.V.
Presentations:

  • Alison Gray, AFABILITY: “Barriers and Challenges Facing the Replacement of Animal Derived Antibodies (ADAs)”
  • João Barroso, Joint Research Centre, European Commission: “Scientific Validity of Non-Animal-Derived Antibodies”
  • Stefan Dübel, Technische Universität Braunschweig: “Animal Free Multiclonal Antibody Generation as a Replacement for Polyclonal Antibodies”
  • Pierre Cosson, University of Geneva: “Recombinant Antibodies: A Complete Toolbox for Academia”
  • Lia Cardarelli, Toronto Recombinant Antibody Centre: “Recombinant Antibody Technology: Taking Antibodies From Bench to Bedside”
  • Katherine Groff, PETA Science Consortium International e.V.: “Strategizing to Optimize the Development and Use of Animal-Free Antibodies in the US”


Session Title: Lessons Learned and Practical Considerations for the Use of In Vitro Exposure Systems to Assess Respiratory Toxicity
Session ID: 128
Day/Time: Tuesday, 31 August, 9–11 am EDT (3–5 pm CEDT)
Chair: Amy Clippinger, PETA Science Consortium International e.V.
Co-Chair: Lawrence Milchak, 3M
Presentations:

  • Lawrence Milchak, 3M: “Key Learnings From In Vitro Vapor and Direct Liquid Exposure Studies for Acute Respiratory Toxicity”
  • Sandra Verstraelen, VITO: “Air Liquid Interface Exposure for Inhalation Testing: Case Studies”
  • Mark Higuchi, US Environmental Protection Agency: “Applying NAMs in BMD Analysis and CFD Modeling to Advance In Vitro Inhalation Toxicity Testing”
  • Vicki Stone, Heriot-Watt University: “Using a Dry Powder Vitrocell System to Expose Respiratory Epithelial Models”
  • Holger Behrsing, Institute for In Vitro Sciences: “Advanced Human 3-Dimensional Test Systems Paired With Modern Exposure Systems: Progress Toward Recreating Physiological-Like Inhalation Exposures”

 

ORAL PRESENTATIONS

Session Title: Human Relevance in Both Dose and Effect for In Vitro Testing of Respiratory Toxicity
Session ID: 156
Day/Time: Tuesday, 24 August, 9–11 am EDT (3–5 pm CEDT)
Chairs: R Vandebriel and HM Braakhuis, the Netherlands National Institute for Public Health and the Environment
Talk Title: Use of Cause-and-Effect Analysis to Optimize the Reliability of In Vitro Inhalation Toxicity Measurements Using an Air-Liquid Interface

Session Title: Alternative Approaches and Predictive Methods to Fish Toxicity Testing
Session ID: 183
Day/Time: Tuesday, 24 August, 12:30–2:30 pm EDT (6:30–8:30 pm CEDT)
Chairs: Véronique Poulsen, L’Oréal and Martin Paparella, Medical University of Innsbruck
Talk Title: Christopher Faßbender, PETA Science Consortium International e.V.: Current Status of the OECD Project on the IATA for Acute Fish Toxicity (PDF)
Talk Title: Martin Paparella, Medical University of Innsbruck: Limitations and uncertainties of acute fish toxicity assessments can be reduced using alternative methods


POSTER PRESENTATIONS

Abstract Number: 43 (PDF)
In Vitro Approach for Assessing Respiratory Toxicity in Human Lung Cells
Amy J. Clippinger1, Sandra Verstraelen,2 Evelien Frijns,2 Frederick Maes,2  Monita Sharma,1 Andreas O. Stucki,1
1PETA Science Consortium International e.V., Germany; 2Flemish Institute for Technological Research (VITO), Belgium

Abstract Number: 129 (PDF)
Rethinking Carcinogenicity Assessment for Agrochemicals
Gina M. Hilton1, Gregory Akerman2, James Baldassari3, Michael Battalora3, Roland Buesen4, Amy J. Clippinger1, Rhian Cope5, Amber Goetz6, A. Wallace Hayes7, Tzippi Kormos8,Anna Lowit2, Stephanie Melching-Kollmuss4, Sabitha Papineni9, Richard C. Peffer10, Brandy Williamson Riffle11, Mitscheli Sanches da Rocha11, Natalia Ryan6, Edward Scollon12, Nicolo Visconti8, Douglas C. Wolf6, Zhongyu Yan9
1PETA Science Consortium International e.V., Germany; 2United States Environmental Protection Agency; 3FMC Corporation, US; 4 BASF SE, Germany; 5Australian Pesticides and Veterinary Medicines Authority; 6Syngenta Crop Protection, LLC, US; 7University of South Florida, US; 8Bayer CropScience LP, US; 9Corteva Agriscience™, US; 10Rich Peffer Toxicology Consulting, LLC, US; 11BASF Corporation, US; 12Valent U.S.A. LLC, US

Abstract Number: 62 (PDF)
Non-Animal Efficacy Testing Approaches for Ectoparasiticides
Katherine Groff1
1PETA Science Consortium International e.V., Germany

Abstract Number: 288 (PDF)
International Approaches to Implementing Alternative Test Methods for Marine Biotoxins in Shellfish
Katherine Groff1, Ankita Pandey1
1PETA Science Consortium International e.V., Germany

Abstract Number: 574 (PDF)
The Changing Face of Chemicals Legislation in India: Opportunities to Minimise Testing on Animals
Ankita Pandey1
1PETA Science Consortium International e.V., Germany

Abstract Number: 839 (PDF)
Successful Development of Recombinant Human Diphtheria Antitoxin: A Project Update
J Brown1, E Wenzel2, L Coombs3, Stefan Dübel2, Paul Stickings3, Thea Sesardic3, Michael Hust2
1PETA Science Consortium International e.V., Germany; 2 Technische Universität Braunschweig, Germany; 3National Institute for Biological Standards and Control, UK

Abstract Number: 965 (PDF)
Human-Relevant Approaches to Assess Eye Corrosion/Irritation Potential of Agrochemical Formulations
Amy J. Clippinger1, Hans A. Raabe2, David G. Allen3, Neepa Choksi3, Anna van der Zalm1, Nicole Kleinstreuer4, João Barroso5
1PETA Science Consortium International e.V., Germany; 2Institute for In Vitro Sciences, US; 3Integrated Laboratory Systems, US; 4National Institute of Environmental Health Sciences, US; 5Joint Research Centre, European Commission, Italy

Abstract Number: 1001 (PDF)
Developing a Defined Approach for Eye Irritation Testing
Neepa Choksi1, Amy J. Clippinger2, Sean Gehen3, Marco Corvaro4, Susanne N. Kolle5, Karin Bentley6, Angela Hofstra7, Monique Inforzato8, Natalia Ryan9, Elizabeth Webb9, Warren Casey10, Nicole Kleinstreuer10, David G. Allen1
1Integrated Laboratory Systems, U.S.; 2PETA Science Consortium International e.V., Germany; 3Corteva Agriscience, U.S.; 4Corteva Agriscience, Italy; 5BASF, Germany; 6FMC Agricultural Solutions, US; 7Syngenta Canada Inc, Canada; 8Syngenta Crop Protection LLC, US; 9Bayer Crop Science, US; 10National Toxicology Program, National Institute of Environmental Health Sciences, US

Abstract Number: 519 (PDF)
Transitioning A549 Cells to FBS-Free Media: Process and Determining Success
Aline Chary1, Servane Contal1, Charlotte Stoffels1, Sébastien Cambier1, Katherine Groff2, Monita Sharma2, Andreas O. Stucki2, Amy J. Clippinger2, Arno C. Gutleb1
1Luxembourg Institute of Science and Technology; 2PETA Science Consortium International e.V., Germany

 

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