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Disclaimer: This table primarily focuses on reconstructed human tissues. The information provided in this table is sourced from various suppliers and may not be complete or fully accurate. Inclusion of any supplier or product does not imply endorsement or recommendation. Chemically defined medium definition is based on Chary et al. 2022.
Tissue model name | Supplier | Organ/system | Tissue detail | Cell types | Chemically defined media* | Facilities | Included in OECD Test Guideline? |
---|---|---|---|---|---|---|---|
SkinEthic HBE | EpiSkin, L’oreal | Bladder | Bladder epithelium | Immortalized human bladder epithelial cells (RT-112) | Yes | France | |
Cartilage model | BioSolution | Cartilage | Cartilage | Primary human chondrocytes | South Korea | ||
3D Osteochondral Model | Alcyomics® | Cartilage | Cartilage | Mesenchymal stem cell-derived chondrocytes and osteoblasts | UK | ||
MCTT HCE™ | BioSolution | Eye | Corneal epithelium | Primary human corneal epithelial cells | South Korea | TG 492 | |
SkinEthic™ HCE | EpiSkin, L’oreal | Eye | Corneal epithelium | Transformed human corneal keratinocytes | Yes | France | TG 492, TG 492B |
LabCyte CORNEA-MODEL | Japan Tissue Engineering | Eye | Corneal epithelium | Primary human corneal epithelial cells | No | Japan | TG 492 |
EpiCorneal™ | MatTek | Eye | Corneal epithelium | Primary human corneal epithelial cells | No | USA/Slovakia | |
EpiOcular™ | MatTek | Eye | Corneal epithelium | Primary human epidermal keratinocytes | No | USA/Slovakia | TG 492 |
Retinal Pigment Epithelium | Newcells Biotech | Eye | Retinal Pigment Epithelium | iPSC-derived retinal pigment cells | UK | ||
RepliGut® Planar | Altis Biosystems | Gut | Small Intestine (duodenum, jejunum, iIleum) or Colon (ascending, transverse or descending) | Primary human intestinal epithelial cells | USA | ||
EpiIntestinal™ | MatTek | Gut | Small intestine epithelium | Primary human small intestinal epithelial cells | No | USA/Slovakia | |
EpiIntestinal™ FT | MatTek | Gut | Small intestine epithelium and interstitium | Primary human small intestinal epithelial cells and fibroblasts | No | USA/Slovakia | |
NuHeart™ | InvivoSciences | Heart | Heart microtissues | iPSC-derived cardiomiocytes | USA | ||
hvCOC, Human Heart-in-a-Jar | Novoheart™ | Heart | Heart microtissues | iPSC-derived cardiomiocytes | Canada | ||
hvCTS | Novoheart™ | Heart | Heart microtissues | iPSC-derived cardiomiocytes | Canada | ||
EpiKidney™(beta) | MatTek | Kidney | Nephron (kidney proximal tubule epithelium) | Primary human proximal tubule epithelial cells | No | USA/Slovakia | |
aProximate™ | Newcells Biotech | Kidney | Nephron (kidney proximal tubule epithelium) | Primary human proximal tubule epithelial cells | Yes | UK | |
Liver model | BioSolution | Liver | Hepatocytes | Stem cell-derived liver cells | South Korea | ||
Hepatopac® | BioIVT | Liver | Hepatocytes | Primary human hepatocytes or immortalized hepatocytes (upcyte®), and stromal cells | No | UK/USA | |
Hepatomune® | BioIVT | Liver | Hepatocytes & Kupfer cells | Primary human hepatocytes or immortalized hepatocytes (upcyte®), stromal cells and Kupffer cells | UK/USA | ||
3D InSight™ Human Liver Microtissues | InSphero | Liver | Hepatocytes & Kupfer cells | Primary human hepatocytes, stromal cells (hepatic endothelial cells) and Kupffer cells | Switzerland/USA | ||
TruVivo® | LifeNet Health | Liver | Hepatocytes | Primary human hepatocytes, stromal cells (inc. endothelial cells) | USA/Worldwide | ||
EpiLiver™(beta) | MatTek | Liver | Hepatocytes | Primary human hepatocytes | No | USA/Slovakia | |
Dopaminergic neuron model | BioSolution | Nervous system | Central nervous system (brain) | Stem cell-derived dopaminergic neurons | South Korea | ||
BrainSim® | AxoSim | Nervous system | Central nervous system (brain) | iPSC-derived neurons and glial cells (astrocytes and oligodendrocytes) | USA | ||
microBrain™ | AxoSim | Nervous system | Central nervous system (brain) | iPSC-derived cortical neurons and glial cells (astrocytes) | USA | ||
NerveSim® | AxoSim | Nervous system | Peripheral nervous system (nerves) | iPSC derived neurons and glial cells (Schwann cells) | USA | ||
SoluOral™ | BioSolution | Oral | Oral epithelium | Oral mucosal epithelial cells | South Korea | ||
SkinEthic™ HGE | EpiSkin, L’oreal | Oral | Gingival epithelium | Primary human gingival keratinocytes | Yes | France | |
SkinEthic™ HO2E | EpiSkin, L’oreal | Oral | Oesophageal epithelium | Immortalized oesophageal epithelial cells (Kyse 510) | Yes | France | |
SkinEthic™ HOE | EpiSkin, L’oreal | Oral | Oral epithelium | Immortalized oral epithelial cells (TR146) | Yes | France | |
EpiGingival™ | MatTek | Oral | Gingival epithelium | Primary human gingival keratinocytes | No | USA/Slovakia | |
EpiGingival™ FT | MatTek | Oral | Gingival epithelium | Primary human gingival keratinocytes and fibroblasts | No | USA/Slovakia | |
EpiOral™ | MatTek | Oral | Oral epithelium | Primary human oral keratinocytes | No | USA/Slovakia | |
EpiOral™ FT | MatTek | Oral | Oral epithelium | Primary human oral keratinocytes and fibroblasts | No | USA/Slovakia | |
EpiOral™ FT LC | MatTek | Oral | Oral epithelium | Primary human oral keratinocytes and Langerhans cells | No | USA/Slovakia | |
Islet model | BioSolution | Panchreas | Stem cells-derived islets | Stem cell-derived human islet cells | South Korea | ||
3D InSight™ Human Islet Microtissues | InSphero | Panchreas | Reaggreated human islet cells | Primary human islet cells | Switzerland/USA | ||
SoluAirway™ | BioSolution | Respiratory | Tracheobronchial epithelium | Primary human tracheal/bronchial epithelial cells | South Korea | ||
AlveolAir™ | Epithelix | Respiratory | Alveolar epithelium | Alveolar epithelial cells (type I and II) and endothelial cells | Yes | Switzerland | |
MucilAir™ | Epithelix | Respiratory | Nasal, tracheal or bronchial epithelium | Primary human nasal, tracheal or bronchial epithelial cells | Yes | Switzerland | |
MucilAir™ HF | Epithelix | Respiratory | Nasal, tracheal or bronchial epithelium incl. fibroblasts | Primary human nasal, tracheal or bronchial epithelial cells and fibroblasts | Yes | Switzerland | |
SmallAir™ HF | Epithelix | Respiratory | Small airway (bronchiolar) epithelium | Small airway epithelial cells and fibroblasts | Yes | Switzerland | |
SmallAir™ | Epithelix | Respiratory | Small airway (bronchiolar) epithelium | Small airway epithelial cells | Yes | Switzerland | |
HiAlv | HiLung | Respiratory | Alveolar epithelium | iPSC-derived alveolar epithelial cells | Japan | ||
HiTrach | HiLung | Respiratory | Tracheobronchial epithelium | iPSC-derived tracheal epithelial cells | Japan | ||
ImmuLUNG™ | ImmuONE™ | Respiratory | Alveolar epithelium | Immortalized human alveolar epithelial cells and alveolar macrophage-like | UK | ||
ALIsens | Invitrolize | Respiratory | Alveolar epithelium | Immortalized alveolar epithelial cells (A549), immortalized endothelial cells (EA.hy926), immortalized macrophage-like cells (dTHP-1) and immortalized dendritic-like cells (THP-1) | No | Luxemburg | |
EpiAirway™ | MatTek | Respiratory | Tracheobronchial epithelium | Primary human tracheal/bronchial epithelial cells | No | USA/Slovakia | |
EpiAirway™ FT | MatTek | Respiratory | Tracheobronchial epithelium | Primary human tracheal/bronchial epithelial cells and stromal fibroblasts | No | USA/Slovakia | |
EpiAlveolar™ | MatTek | Respiratory | Alveolar epithelium | Primary alveolar epithelial cells (type I and II), pulmonary fibroblasts and pulmonary endothelial cells (possible with immortalized macrophage-like cells, THP-1) | No | USA/Slovakia | |
EpiNasal™(beta) | MatTek | Respiratory | Nasal epithelium | Primary human nasal epithelial cells | No | USA/Slovakia | |
Small Airway Epithelial Cell Model | Newcells Biotech | Respiratory | Small airway (bronchiolar) epithelium | Small airway epithelial cells | UK | ||
KeraSkin-FT™ | BioSolution | Skin | Full thickness thickness skin (epidermis & dermis) – Korean | Primary human keratinocytes & fibroblasts | South Korea | ||
KeraSkin-M™ | BioSolution | Skin | Reconstructed epidermis (pigmented) – Korean | Primary human keratinocytes & melanocytes | South Korea | ||
KeraSkin™ | BioSolution | Skin | Reconstructed epidermis (Korean) | Primary human keratinocytes | South Korea | TG 439 | |
Skimune® | Alcyomics® | Skin | Full thickness reconstructed skin tissue (explant) – dermis, epidermis; incl. Blood samples | Full thickness skin tissue (explant) incl. Peripheral Blood Mononuclear Cells | UK | ||
Skimune® Epi | Alcyomics® | Skin | Reconstructed epidermis | Primary human keratinocytes | UK | Alternative for TG 431 & TG 439 | |
3D Innervated Skin Model | Alcyomics® | Skin | Full thickness reconstructed skin tissue (epidermis & dermis) incl. neurons | Primary human keratinocytes & fibroblasts, incl. iPSC-derived Schwann cells & neurons | UK | ||
Skimune 3D® | Alcyomics® | Skin | Full thickness reconstructed skin tissue (epidermis & dermis) | Primary human keratinocytes & fibroblasts | UK | ||
3D bioprinted | Atlantis Bioscience | Skin | Reconstructed epidermis (pigmented) | Primary human keratinocytes, melanocytes, immune cells (macrophages), sebocytes & endothelial cells | Singapore | ||
Adult human skin, full thickness | Atlantis Bioscience | Skin | Full thickness skin tissue (explant) – dermis, epidermis | Full thickness skin tissue (explant) | Singapore | ||
Ex vivo explants | Creative Bioarray | Skin | Full thickness skin tissue (explant) – dermis, epidermis | Full thickness skin tissue (explant) | USA/Germany | ||
Full Thickness Skin Model | Creative Bioarray | Skin | Full thickness reconstructed skin tissue (epidermis & dermis) | Primary human keratinocytes & fibroblasts | USA/Germany | ||
Neurodermatology Cell Model | Creative Bioarray | Skin | Full thickness reconstructed skin tissue (epidermis & dermis) incl. sensory neurons | Primary human keratinocytes, sensory neurons | USA/Germany | ||
Pigmented Skin Model | Creative Bioarray | Skin | Full thickness reconstructed skin tissue (epidermis & dermis, pigmented) | Primary human keratinocytes, fibroblasts & melanocytes | USA/Germany | ||
Reconstructed Human Epidermis | Creative Bioarray | Skin | Reconstructed epidermis | Primary human keratinocytes | USA/Germany | ||
CTISkin® | CTIBiotech | Skin | Full thickness skin tissue (explant) – dermis, epidermis | Full thickness skin tissue (explant) | Singapore | ||
Sebocyte 3D model | CTIBiotech | Skin | Hypodermis – Sebaceous gland | Sebocytes | France | ||
DNSKinFT™ | DeNova Sciences | Skin | Full thickness thickness skin (Asian) | Primary human keratinocytes & fibroblasts | Yes | Singapore | |
DNSkin™ | DeNova Sciences | Skin | Reconstructed epidermis (Asian) | Primary human keratinocytes | Yes | Singapore | |
EpiSkin™ Human Epidermis | EpiSkin, L’oreal | Skin | Reconstructed epidermis | Primary human keratinocytes | France | TG 431 | |
SkinEthic™ RHE-LC | EpiSkin, L’oreal | Skin | Reconstructed epidermis & Langerhans | Primary human keratinocytes & Langerhans cells | France | ||
SkinEthic™ RHPE | EpiSkin, L’oreal | Skin | Reconstructed epidermis (pigmented) | Primary human keratinocytes & melanocytes | France | ||
SkinEthic™ RHE | EpiSkin, L’oreal | Skin | Reconstructed epidermis | Primary human keratinocytes | Yes | France | TG 431, TG 439 |
T-Skin™ | EpiSkin, L’oreal | Skin | Full thickness reconstructed skin tissue (epidermis & dermis) | Primary human keratinocytes & fibroblasts | France | ||
NativeSkin® | Genoskin | Skin | Full thickness skin tissue (explant) – dermis, epidermis | Full thickness skin tissue (explant) | Yes | France /USA | |
HypoSkin® | Genoskin | Skin | Full thickness skin tissue (explant) – dermis, epidermis & hypodermis (adipose) | Full thickness skin tissue (explant) | Yes | France /USA | |
LabCyte EPI-MODEL | Japan Tissue Engineering | Skin | Reconstructed epidermis | Primary human keratinocytes | No | Japan | TG 431, TG 439 |
LabCyte EPI-MODEL 6D | Japan Tissue Engineering | Skin | Reconstructed epidermis | Primary human keratinocytes | No | Japan | |
3D ADIPOPrint | Labskin Creations | Skin | Hypodermis tissue (adipose) | Adipose stem cell-derived adipocytes | France | ||
3D PIGMENTSkin | Labskin Creations | Skin | Full thickness reconstructed skin tissue (epidermis & dermis, pigmented) | Primary human keratinocytes, fibroblasts & melanocytes | France | ||
Bioprinted Human Pigmented Epidermis | Labskin Creations | Skin | Reconstructed epidermis (pigmented) | Primary human keratinocytes & melanocytes | France | ||
LabSkin Reconstructed Human Epidermis | Labskin Creations | Skin | Reconstructed epidermis | Primary human keratinocytes | France | ||
3D SEBOSkin | Labskin Creations | Skin | Full thickness reconstructed skin tissue (epidermis & dermis) incl. sebaceous glands | Primary human keratinocytes, fibroblasts & iPSC-derived sebocytes | France | ||
3D VASCULOSkin | Labskin Creations | Skin | Full thickness reconstructed skin tissue (epidermis & dermis) incl. endothelial cells | Primary human keratinocytes, fibroblasts & endothelial cells | France | ||
EpiDerm™ | MatTek | Skin | Reconstructed epidermis | Primary human keratinocytes | No | USA/Slovakia | TG 431, TG 439, TG 498 |
EpiDerm™ FT | MatTek | Skin | Full thickness reconstructed skin tissue (epidermis & dermis) | Primary human keratinocytes & fibroblasts | No | USA/Slovakia | |
MelanoDerm™ | MatTek | Skin | Reconstructed epidermis (pigmented) – Caucasian, African or Asian | Primary human keratinocytes & melanocytes | No | USA/Slovakia | |
Phenion® FT AGED | Phenion | Skin | Full thickness reconstructed skin tissue (epidermis & dermis) – senescent | Primary human keratinocytes & fibroblasts | Germany | ||
Phenion® FT LONG-LIFE | Phenion | Skin | Full thickness reconstructed skin tissue (epidermis & dermis) – aged | Primary human keratinocytes & fibroblasts | Germany | ||
Phenion® FT Skin Model | Phenion | Skin | Full thickness reconstructed skin tissue (epidermis & dermis) | Primary human keratinocytes & fibroblasts | Germany | Alternative for TG439 | |
Silabskin® FT | Silab | Skin | Full thickness thickness skin (epidermis & dermis) | Primary human keratinocytes & fibroblasts | France | ||
Silabskin® RE | Silab | Skin | Reconstructed epidermis | Primary human keratinocytes | France | ||
Straticell RHE | StratiCELL | Skin | Reconstructed epidermis | Primary human keratinocytes | Belgium | ||
Straticell RHE-huSN | StratiCELL | Skin | Reconstructed epidermis & sensory neurons | Primary human keratinocytes & iPSC-derived sensory neurons | Belgium | ||
Straticell RHE-MEL | StratiCELL | Skin | Reconstructed epidermis (pigmented) | Primary human keratinocytes & melanocytes | Belgium | ||
Straticell adipose model | StratiCELL | Skin | Hypodermis tissue (adipose) | Human white pre-adipocytes, human differentiated white adipocytes, or immortalized mouse preadipocyte cells (3T3L1) | Belgium | ||
SkinEthic™ HVE | EpiSkin, L’oreal | Vagina | Vaginal epithelium | Immortalized human vaginal epithelial cells (A431) | Yes | France | |
EpiVaginal™ | MatTek | Vagina | Vaginal epithelium | Primary human ectocervical cells (custom: + dendritic cells) | No | USA/Slovakia | |
EpiVaginal™ FT | MatTek | Vagina | Vaginal epithelium | Primary human ectocervical cells and fibroblasts (custom: + dendritic cells) | No | USA/Slovakia |