Priorities and Opportunities for Replacement of Animal Tests: A Discussion with NICEATM and ICCVAM Leadership

Society of Toxicology Ancillary Meeting

This meeting will provide a forum for discussion with Dr. Warren Casey, director of the U.S. NTP (National Toxicology Program) Interagency  Center for the Evaluation  of Alternative  Toxicological Methods  (NICEATM) and Dr. Anna Lowit, senior scientist at the U.S. Environmental Protection Agency (U.S. EPA) and co-chair of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM). ICCVAM, with support  from  NICEATM, facilitates  the development, validation, and regulatory acceptance of new and revised regulatory test methods that support the 3Rs.

Drs. Casey and Lowit will provide a brief introduction on recent ICCVAM and NICEATM activities, including:

• ICCVAM acute systemic toxicity efforts
• Roadmap for replacement of the acute toxicity “6-pack” at the U.S. EPA
• Efforts toward international harmonization of non-animal test methods
• Developing best practices for use of in vitro to in vivo extrapolation (IVIVE)

Following a brief overview, this meeting is intended to be an open discussion of the challenges and opportunities to replace current regulatory requirements using animals. Participants are asked to come prepared to share experiences and perspectives on near-term opportunities for the global replacement of animal-based toxicology test methods. Specific examples of challenges to the implementation of alternatives within your organization are encouraged.

To download a shareable flyer, please click here.