European Commission Updates REACH Annex VII Skin Sensitisation Data Requirements

REACH Annex VII has been updated by the European Commission to require that non-animal methods be used to meet the skin sensitisation information requirement. An in vivo study may only be conducted if the in vitro or in chemico test methods are not applicable or if the results obtained from those studies are not adequate for classification and risk assessment. Registrants should use the OECD adverse outcome pathway for skin sensitisation, OECD test guidelines (TG) 442C and 442D, and the recently adopted Human Cell Line Activation Test (OECD TG 442E), to meet the REACH skin sensitisation data requirements. The updated Annex is available here.