The Organisation for Economic Co-operation and Development (OECD) published eight new case studies of diverse read-across approaches supported by various types of data from New Approach Methodologies (NAMs).
These case studies provide concrete examples illustrating how NAMs applied to the Adverse Outcome Pathway (AOP) framework can deliver predictions that are practical and fit for regulatory use.
No. 1: Case Study on the Use of an Integrated Approach to Testing and Assessment (IATA) and New Approach Methods to Inform a Theoretical Read-Across for Dermal Exposure to Propylparaben from Cosmetics
No. 2: Case Study on the Use of Integrated Approaches for Testing and Assessment for Systemic Toxicity Arising from Cosmetic Exposure to Caffeine
No. 3: Case Study on the Use of Integrated Approaches for Testing and Assessment for 90-Day Rat Oral Repeated-Dose Toxicity of Chlorobenzene-Related Chemicals
No. 4: Case Study on the Use of Integrated Approaches for Testing and Assessment to Inform Read-Across of p-Alkylphenols: Repeated-Dose Toxicity
No. 5: Prediction of a 90 day Repeated Dose Toxicity Study (OECD 408) for 2-Ethylbutyric Acid Using a Read-Across Approach from Other Branched Carboxylic Acids
No. 6: Read-Across Based Filling of Developmental and Reproductive Toxicity Data Gap for Methyl Hexanoic Acid
No. 7: Identification and Characterisation of Parkinsonian Hazard Liability of Deguelin by an AOP-Based Testing and Read-Across Approach
No. 8: Mitochondrial Complex-III-Mediated Neurotoxicity of Azoxystrobin – Read-Across to Other Strobilurins
For more information on OECD IATA work, please click here.