OECD Publishes New Adverse Outcome Pathway Series

The Organisation for Economic Co-operation and Development (OECD) has published a new series of documents on adverse outcome pathways (AOPs) for regulatory risk assessment. In addition to a handbook which supplements the Guidance Document for developing and assessing AOPs, four new AOPs were published:

• Adverse Outcome Pathway on Chronic Binding of Antagonist to N-Methyl-D-Aspartate Receptors (NMDARs) During Brain Development Induces Impairment of Learning and Memory Abilities
• Adverse Outcome Pathway on Aromatase Inhibition Leading to Reproductive Dysfunction (in Fish)
• Adverse Outcome Pathway on Alkylation of DNA in Male Pre-Meiotic Germ Cells Leading to Heritable Mutations
• Adverse Outcome Pathway on Protein Alkylation Leading to Liver Fibrosis

AOPs are the central element of a toxicological knowledge framework and are built to support chemical risk assessment through mechanistic reasoning. The documents can be found here.