OECD Publishes Guidelines for New Non-Animal Skin Sensitisation Test Methods

OECD has published two new guidelines to classify skin sensitisers (GHS Cat. 1) and non-sensitisers in the context of integrated approaches to testing and assessment (IATA). The Direct Peptide Reactivity Assay (DPRA), an in chemico method, addresses the molecular initiating event of the skin sensitisation adverse outcome pathway (AOP) and the ARE-Nrf2 Luciferase Test Method (KeratinoSensTM), an in vitro method, addresses the second key event in the skin sensitisation AOP.