EURL ECVAM Issues Recommendations on Animal-Free Approaches for Skin Sensitisation Testing

Building upon their 2013 strategy for the replacement of tests on animals for skin sensitisation testing, the European Union Reference Laboratory for alternatives to animal testing (EURL ECVAM) has published its recommendations on the use of non-animal approaches for regulatory assessment of the endpoint. The use of in chemico and in vitro methods within Defined Approaches is recommended for identifying potential skin allergens. The Defined Approaches may include use of the direct peptide reactivity assay (DPRA), the KeratinoSens assay, or the human cell line activation test (h-CLAT), as well as the two latest methods for skin sensitisation testing, the LuSens and U-SENS assays. More information can be found here.