The European Chemicals Agency (ECHA) has updated its Read-Across Assessment Framework, which is a tool used to examine predictions based on read-across in REACH dossiers. The scope of the document has been expanded to include scientific assessment of the environmental fate and hazards of chemicals, and six scenarios have been added.
In addition, ECHA published a new document on using read-across for multi-constituent substances (MSCs) and UVCBs (substances of unknown or variable composition, complex reaction products or biological materials) describing key issues for assessing and addressing the complexity of read-across approaches for these substances. For illustration, the document contains example model cases. When the understanding of the complexity of read-across with MCSs and UVCBs has improved, the RAAF will be developed further based on this document.