US EPA HPV Challenge Program

Consortium member PETA US campaigned successfully for guidance on reducing animal use to be implemented into the EPA’s High Production Volume (HPV) Challenge Program. Throughout the programme’s 12-year duration, PETA US scientists reviewed and commented on hundreds of test plans – every one in which testing on vertebrate animals was proposed – in order to ensure compliance with guidelines on reducing animal use. Building on this work, scientists from PETA US published a retrospective analysis of animal use in the HPV chemical-testing program, concluding that the application of read-across was the single most effective means of reducing animal testing.